Jay Hesselberth is Co-Founder of Andon Bio, a biotech startup pioneering tRNA measurement technologies to unlock the limits of protein expression and power predictive sequence design.

Jay is a Professor in the Department of Biochemistry and Molecular Genetics at the University of Colorado School of Medicine, where he trained at the University of Washington, and has built a distinguished career in RNA biology, technology development, and RNA therapeutics.

With over 116 publications and more than 4,600 citations, Jay is a leading voice in RNA science, with deep expertise in nanopore sequencing, tRNA biology, and next-generation sequencing method development.

At the Hesselberth Lab (CU Anschutz), Jay leads a collaborative team of RNA biologists, technology developers, and data analysts, and works with clinicians at Children's Hospital Colorado to develop RNA therapies for pediatric genetic diseases.

Andon Bio translates Jay's foundational tRNA research into commercial tools that measure charged tRNAs to reveal bottlenecks in protein expression, with applications spanning biotherapeutics, mRNA medicines, and synthetic biology.